Lobna M ElNabil

Ain shams university, Neurology Department, Egypt

Abstract Title: Cerebral Hemodynamics Changes in Patients with Relapsing Remittent Multiple Sclerosis: An Egyptian study

Biography:

Professor Lobna M Elnabil has completed her MD in neurology at the age of 32 years from Ain shams University, Cairo , Egypt and professor of Neurology in Ain shams university since 2015. She is the member of MS unit in Ain shams university hospital. Reviewer at Egyptian Journal of Neurology, Psychiatry and Neurosurgery. Member of Egyptian society of Neurology, Psychiatry and Neurosurgery.

Research Interest:

Multiple sclerosis a demyelinating disease of the central nervous system. Although the currently predominant view is that of an autoimmune inflammatory condition, changes in brain vasculature can occur and contribute to pathophysiology. Objectives: To evaluate the cerebral hemodynamic changes in patients with relapsing remittent multiple sclerosis (RRMS) using transcranial color-coded Doppler (TCCD), and to evaluate brain tissue perfusion using magnetic resonance image (MRI) perfusion. Methods: Forty patients diagnosed with RRMS according to revised McDonald criteria 2017 in remission state were recruited to this comparative cross-sectional study. Forty age and sex matched healthy controls were included in the study. Detailed medical and neurological assessment were done. All participants underwent assessment of cerebral hemodynamics through TCCD ns assessment of cerebral perfusion by MRI perfusion technique; cerebral blood volume (CBV), cerebral blood flow (CBF), and mean transit time (MTT) were calculated. Results: The mean MCA blood flow in supine and erect position were 84.16±16.93 cm/sec and 80.63±15.78 cm/sec respectively BHI is impaired in 55 % of patients .There is statistically significant difference as CBV, CBF and MTT of the NAWM between both RRMS group and control group . There is statistically significant difference as regard CBF between the plaque and the NAWM within the RRMS group; CBF is significantly higher within the NAWM with mean value( 71.34) compared to mean CBF within the plaque ( 58.07) indicating more perfusion of the NAWM with p value 0.025. Conclusions: Cerebrovascular hemodynamic insufficiency in MS may be secondary to the downstream effects of neuro-inflammatory cascades.