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Zhi-Peng Guo

 

Zhi-Peng Guo

Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, China

Abstract Title: Thought induction psychotherapy modulating the brain topology of functional network in major depressive disorder

Biography:

Zhi-Peng Guo was a PhD student of Beijing Hospital of Traditional Chinese Medicine, Capital Medical University. He has published more than 11 papers in reputed journals.

Research Interest:

Thought Induction Psychotherapy (TIP) is effective in regulating the depressive symptom in major depression disorder (MDD). Our study aimed to explore the application of TIP treatment in patients with MDD and altered brain topological organization of functional networks. Methods: Nineteen patients with MDD were enrolled in the current study. Six weeks of TIP treatments were conducted in MDD patients, and the resting-state functional magnetic resonance imaging (rs-fMRI) data were collected before and after TIP treatment. Graph theory method and network-based statistics (NBS) analysis were used to detect abnormal topological organization of functional network in MDD patients before and after TIP treatment. Correlation analysis was performed to characterize the relationship between altered network properties and neuropsychological scores. Results: After six weeks of TIP treatment, MDD patients exhibited increased degree centrality (DC) in left anterior cingulate cortex (ACC) and nodal efficiency (NE) in left anterior insula, and decreased NE in right precuneus. NBS results showed that MDD patients exhibited reduced connectivity between default mode network (DMN)-frontoparietal network (FPN), DMN-cingulo-opercular network (CON), and FPN-CON. In addition, the change of NE in right precuneus was negatively correlated with the change in Hamilton Depression scores, and the change of NE in left anterior insula was negatively correlated with the change in dopamine. Conclusion: These findings demonstrated that TIP may be an effective method in reducing the depressive symptom severity in MDD patients, mainly through modulating the brain topological organization. Our study may provide insights into the underlying brain mechanism of TIP treatment in MDD.